New database searches on CBD and Epilepsy

APA Style, Week 13 Blog Post, ,


 
 
 
 
 
I believe it is best to conduct my research utilizing a Quantitative experiment approach which will help me explain in detail my research paper with the proven effects that CBD has on epilepsy seizures. I conducted my last 5 searches using Forsyth Library. All my searches came from health and medicine, nursing and allied health premium and ProQuest. ProQuest database has most of the information I need to write my research paper. There are outside databases that also have allot of relative information I plan to use as well.
Search 1

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  • Peer Reviewed
  • 788 search results
  • Databases searched -Health and Medicine- Nursing and Allied Health Premium- ProQuest
  • Advance Search- cannabinoid epilepsy
  • Boolean Search-
  • Article of Interest- Trial of cannabidiol for drug-resistant seizures in the dravet syndrome.

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Orin, D., Helen, C. J., Laux, L., Marsh, E., Miller, I., Rima, N., . . . Wright, S. (2017). Trial of cannabidiol for drug-resistant seizures in the dravet syndrome. The New England Journal of Medicine, 376(21), 2011-2020. doi:http://dx.doi.org.ezproxy.fhsu.edu:2048/10.1056/NEJMoa1611618
This study was a doubled blind conducted on a 120 randomly selected young children. There are many types of Epilepsy, but this specific form has a high mortality rate. I read about the research they conducted, and it appeared from what I read that it was particular difficult for some the researchers whom had young children the same ages as the participants for this study.

 
 
 
 
 
 
Search 2

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  • Peer Reviewed
  • 505 search results
  • Databases searched -Health and Medicine- Nursing and Allied Health Premium- ProQuest
  • Advance Search- cannabinoid epilepsy
  • Boolean Search- treatment
  • Article of Interest- Cannabidiol in patients with treatment-resistant epilepsy: An open-label interventional trial.

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  • 10-years
  • Cited by (131)
  • References (27)

 
This study was done on a random selection of children and young adults from ages (1-30)  who have severe, childhood-onset  epilepsy where traditional prescription medicine treatment  was resistant. The study found that  In the past few years, enormous interest has been generated by social and news media about the beneficial effects of non-purified medical marijuana, with high ratios of cannabidiol to tetrahydrocannabinol, in children with treatment-resistant epilepsies.
Devinsky, O., Marsh, E., Friedman, D., Thiele, E., Laux, L., Sullivan, J., . . . Cilio, M. R. (2016). Cannabidiol in patients with treatment-resistant epilepsy: An open-label interventional trial. The Lancet Neurology, 15(3), 270-278. doi:http://dx.doi.org.ezproxy.fhsu.edu:2048/10.1016/S1474-4422(15)00379-8 

 
 
 
 
 
 
Search 3

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  • Peer Reviewed
  • 346 search results
  • Databases searched -Health and Medicine- Nursing and Allied Health Premium- ProQuest
  • Advance Search- cannabinoid epilepsy
  • Boolean Search-Alternative
  • Article of Interest- Evidence for cannabis and cannabinoids for epilepsy: A systematic review of controlled and observational evidence

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Researches of this article found proof that cannabinoid was used as an alternative to treat different forms of epilepsy. The study also concluded that there was a 50% reduction in seizures.
 
Stockings, E., Zagic, D., Campbell, G., Weier, M., Hall, W. D., Nielsen, S., . . . Degenhardt, L. (2018). Evidence for cannabis and cannabinoids for epilepsy: A systematic review of controlled and observational evidence. Journal of Neurology, Neurosurgery and Psychiatry, 89(7), 741. doi:http://dx.doi.org.ezproxy.fhsu.edu:2048/10.1136/jnnp-2017-317168


 
 
 
 
 
Search 4

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  • Peer Reviewed
  • 156 search results
  • Databases searched -Health and Medicine- Nursing and Allied Health Premium- ProQuest
  • Advance Search- cannabinoid epilepsy
  • Boolean Search-Young Children
  • Article of Interest- Cannabidiol for epilepsy: Trying to see through the haze

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The main limitations of this study are its open-label, observational nature; the short follow-up time of only 12 weeks; the absence of a control group; and the high prevalence of clobazam use. Despite these caveats, the study constitutes the largest and best prospective research so far on the use of cannabidiol for the treatment of epilepsy Strengths include the careful design with prospectively determined baseline seizure frequency, prospective diary data, large sample size from multiple epilepsy centers and the use of a high-quality purified cannabidiol extract of known content and purity.
Detyniecki, K., & Hirsch, L. J. (2016). Cannabidiol for epilepsy: Trying to see through the haze. The Lancet Neurology, 15(3), 235-237. doi:http://dx.doi.org.ezproxy.fhsu.edu:2048/10.1016/S1474-4422(16)00002-8
 

 
 
 
 
 
 
Search 5

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  • Peer Reviewed
  • 475 search results
  • Databases searched -Health and Medicine- Nursing and Allied Health Premium- ProQuest
  • Advance Search- cannabinoid epilepsy
  • Boolean Search- Pain
  • Article of Interest- Weeding out bad waves: Towards selective cannabinoid circuit control in epilepsy
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  • 10-year range 
  • Cited by (33)
  • References (153)

The researchers in this study  highlight emerging principles of cannabinoid circuit control and plasticity, and discuss their relevance for epilepsy and related comorbidities. New insights into cannabinoid signalling may facilitate the translation of the recent interest in cannabis-related substances as antiseizure medications to evidence-based treatment strategies.
Soltesz, I., Alger, B. E., Kano, M., Lee, S., Lovinger, D. M., Ohno-shosaku, T., & Watanabe, M. (2015). Weeding out bad waves: Towards selective cannabinoid circuit control in epilepsy. Nature Reviews.Neuroscience, 16(5), 264-277. doi:http://dx.doi.org.ezproxy.fhsu.edu:2048/10.1038/nrn3937
 Final Thoughts
I feel that I have reached saturation and do not feel a need to make any additional searches. I am open to any suggestions from my classmates or professor. I am not a research Guru yet, but I feel that I have an enormous amount of proven material to choose from to support my findings that I plan to write about. I also feel confident because I have used CBD in the past for other health issues particularly sciatic nerve pain, which comes from lower back injuries so I know for a fact this natural medicine works for all types of medical issues besides epilepsy seizures.
 
 

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